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Q
Quercetin [Telomerase Inhibitors/Quercetin, Telomerase Activators/Product B/Quercetin (149), Wikipedia, Links, Images, Video, Papers, Patents, Books, LibCong, Amazon, LifeExtension; Links/Quercetin in foods; Apples, Onions; Quercetin solubilities, Quercetin extraction (Papers, Patents, Books); Images/Quercetin Molecule; Side effects; Sources; Extraction; Toxicity; Bioflavonoid Skin Creams - Quercetin Supplements, Quercetin Skin Creams; Rutin, Rutin Supplements, Rutin Skin Creams; Hesperidin, Hesperidin Supplements, Hesperidin Skin Creams]. Quercetin is potent in gene silencing and in activating the SIRT1 gene, "a sirtuin-activating compound...reported to extend the life span of fruit flies & nematodes", found in grapes, grape skins, apples, green tea, onions, red onions, red wine, tomatoes, (0), [113]. See Resveratrol & Quercetin by James South. Quercetin is a small molecule telomerase inhibitor (for cancer cells) and a small molecule SIRT1 activator, like resveratrol. According to Product B literature, quercetin activates transcription of hTERT in human fibroblasts, and may be taken at 1 mg to 1500 mg twice daily to lengthen telomeres. Quercetin chelates both copper and iron, helping it both oppose the metastasis or spread of cancer via copper and helping it to protect hippocampal mitrochondria against copper and iron, opposing cognitive decline, dementia, and Alzheimer's Disease. See the role of copper in cancer metastasis. Quercetin reduces the expression of an enzyme that produces sorbitol [Images, Books, LibCong, Amazon, Wikipedia, LifeExtension], a sugar alcohol associated with cataracts. Quercetin also increases markers of nitric oxide production and reduces the concentration of a vasoconstricting factor. Quercetin...opens up COPD-inflicted airways. It restores normal elasticity of lung tissue and reduces inflammation. Just as important, it reduces production of the protein-melting enzymes that dissolve alveolar walls, helping to retain the lungs' normal architecture and function." - Anne Buckley (2012), Quercetin: Broad-Spectrum Protection, Life Extension Magazine, September 2012. Finally, quercetin stimulates pancreatic cells [Links] controlling blood glucose levels in diabetics and non-diabetics. Note that quercetin inhibits LDL oxidation, and that quercetin alone produces an up to 60% increase in life span. Quercetin inhibits cardiovascular disease. A high intake of quercetin and related flavonoids resulted in 68% fewer deaths from heart disease than for those with the lowest intake of quercetin. (Anne Buckley, Quercetin: Broad-spectrum protection, Life Extension Magazine, Sept 2012). Quercetin lowers LDL cholesterol while elevating HDL cholesterol to lower the LDL/HDL cholesterol ratio. This lowers the expression of caveolin-1 (gene CAV1), allowing cells to recover from senescent state, and making the onset of the senescent state less likely. Quercetin is a potent anticancer nutraceutical, effecive in chemoprevention of lung cancer, liver cancer, and colon cancer. It is also useful in chemoprevention of prostate cancer and breast cancer. Quercetin is also useful in treating COPD (chronic obstructive pulmonary disease). Futhermore, quercetin is antiviral and antibacterial. Quercetin improves the biovailability of resveratrol. Lecithin (first isolated from egg yolks, see also soy lecithin and phosphatidylcholine) enhances the bioavailability of polyphenols, including resveratrol and quercetin.
A combination of quercetin and rutin (a blood-thinning antiplatelet glycoside of quercetin) was shown to rejuvenate drying skin cells that refused to replicate, so that they began to reproduce again. (Chondrogianni, Kapeta, Chinou, Vassilatou, and Papassideri, 2010), quoted in Gary Goldfaden MD and Robert Goldfaden (2012), How Bioflavonoids Create Youthful Skin Tone, Life Extension Magazine, November 2012 [Dr.Robert]. Quercetin also improves the synthesis of collagen in skin. (Ref). Quercetin has antihistamine properties for counteracting histamine in hives and watering eyes produced by an allergic reaction involving immune reaction to foreign particles. Three bioflavonoids for skin creams, quercetin, rutin, and hesperidin, can be used in topical skin creams to "prevent and reverse wrinkles, reduce the appearance of age spots, and even fight spider veins and varicose veins".
See also Vincent C. J. de Boer, Marcus C. de Goffau, Ilja C. W. Arts, Peter C. H. Hollman, and Jap Keijer (2006), SIRT1 stimulation by polyphenols is affected by their stability and metabolism, Mechanisms of Aging and Development, 127 (2006) 618-627, which was suggested by a correspondent 12/30/2010. The paper focuses on SIRT1 in "HT29" colon cancer cells, and SIRT1 interactions with quercetin, resveratrol, EGCG, and other polyphenols under varying conditions.
"Proteasome activities and function are decreased upon replicative senescence, whereas proteasome activation confers enhanced survival against oxidative stress, lifespan extension and maintenance of the young morphology longer in human primary fibroblasts. Several natural compounds possess anti-ageing/anti-oxidant properties. In this study, we have identified quercetin (QUER) and its derivative, namely quercetin caprylate (QU-CAP) as a proteasome activator with anti-oxidant properties that consequently influence cellular lifespan, survival and viability of HFL-1 primary human fibroblasts. Moreover, when these compounds are supplemented to already senescent fibroblasts, a rejuvenating effect is observed." after Niki Chondrogiannia, Suzanne Kapetaa, Ioanna Chinoub, Katerina Vassilatouc, Issidora Papassiderid, Efstathios S. Gonosa (2010), Anti-ageing and rejuvenating effects of quercetin, Experimental Gerontology, Volume 45, Issue 10, October 2010, Pages 763–771.
Search Test:
Check on whether or not (like resveratrol) quercetin phosphorylates existing cytosolic hTERT [Images, Papers, Books]. Quercetin tests produced longer telomeres in fibroblasts, according to Product B/Quercetin.

References
[1] Kampkotter A, Timpel C, Zurawski RF, et al. (2008),
Increase of stress resistance and life span of Caenorhabditis elegans by quercetin,
Comp Biochem Physiol B Biochem Mol Biol 2008 Feb;149(2):314-23.
[2] Kapiszewska M, Cierniak A, Elas M, Lankoff A. (2007),
Life span of etoposide-treated human neutrophils is affected by antioxidant ability of quercetin,
Toxicol In Vitro 2007 Sep;21(6):1020-30.
[3] Pietsch K, Saul N, Menzel R, Sturzenbaum SR, Steinberg CE (2009), Quercetin mediated life span extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43, Biogerontology 2009 Oct;10(5):565-78.
[4] Chondrogianni N, Kapeta S, Chinou I, Vassilatou K, Papassideri I, Gonos ES (2010), Anti-ageing and rejuvenating effects of quercetin, Exp Gerontol 2010 Oct;45(10):763-71.
[5] Hubbard GP, Wolffram S, Lovegrove JA, Gibbins JM (2004),
Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans, J Thromb Haemost 2004 Dec;2(12):2138-45.
[6] Granado-Serrano AB, Martín MÁ, Bravo L, Goya L, Ramos S. (2012),
Quercetin attenuates TNF-induced inflammation in hepatic cells by inhibiting the NF-kB pathway, Nutr Cancer 2012 May;64(4):588-98.
[7] Aherne SA, O'Brien NM. (1999),
Protection by the flavonoids myricetin, quercetin, and rutin against hydrogen peroxide-induced DNA damage in Caco-2 and Hep G2 cells, Nutr Cancer 1999;34(2):160-6.
[8] Morrow DM, Fitzsimmons PE, Chopra M, McGlynn H. (2001), Dietary supplementation with the anti-tumour promoter quercetin: its effects on matrix metalloproteinase gene regulation, Mutat Research 2001 Sep 1;480-481:269-76.
[9] Bach A, Bender-Sigel J, Schrenk D, Flugel D, Kietzmann T. (2010),
The antioxidant quercetin inhibits cellular proliferation via HIF-1-dependent induction of p21WAF, Antioxid Redox Signal 2010 Aug 15;13(4):437-48.
[10] Boots AW, Haenen GR, Bast A. (2008),
Health effects of quercetin: from antioxidant to nutraceutical,
Eur J Pharmacol 2008 May 13;585(2-3):325-37.
[11] Zhang M, Swarts SG, Yin L, et al. (2011),
Antioxidant properties of quercetin, Adv Exp Med Biol 2011;701:283-9.
[12] Bhaskar S, Shalini V, Helen A. (2011),
Quercetin regulates oxidized LDL induced inflammatory changes in human PBMCs by modulating the TLR-NF-kappaB signaling pathway, Immunobiology 2011 Mar;216(3):367-73.
[13] Maria Russo, Carmela Spagnuolo, Idolo Tedesco, Stefania Bilotto, Gian Luigi Russo (2012), The flavonoid quercetin in disease prevention and therapy: Facts and fancies [PDF],
Biochemical Pharmacology, Volume 83, Issue 1, 1 January 2012, Pages 6–15.
[14] Naasani I, Oh-Hashi F, Oh-Hara T, Feng WY, Johnston J, Chan K, et al. (2003),
Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo, Cancer Research 2003;63:824–30.

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