Longevity Supplement Vendors

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Highlight Links
List of Vendors
Health Food Stores in Wichita, KS
Sprouted Bread Vendors
Bodybuilding Supplements and Equipment
Astragalus, Astragalus Root Extract, and Astragalosides, with Toxicology

[38s] Anti-Aging Pharmaceutical Vendors. || See product notes from Offshore Pharmacy,
International Anti-Aging Systems, Life Extension magazine, Biogenesis cross-references,
Dr. Ray Sahelian's descriptions, Physician Formulas. || PDR | PDR Contraindications
Pharmaceutical Companies Index | Virtual Library Pharmacy Page | Anti-Aging Research.
Yahoo Links: Supplement Links | Specific Drugs and Medications | Health/Pharmacy | Health
Health/Alternative | Hormones | Drugs & Medications | Nutrition | Diseases | Medicine || Google ||
Google links on bulk pharmaceuticals | bulk herbs | bulk chemicals | bulk medicine || Quality Counts
Cross-Reference List of Anti-Aging Medicines | International Anti-Aging Systems Medicine Cross-Reference
House of Nutrition - Brand Name Selection. || Life Extension Products || IAAS Products | Vitacost
The Professional Supplement Center - Brand selection. || HealthPricer - Comparison Shopping for Health.
The Vitamin Shoppe - Brand name selection. || Google/Anti-Aging Supplements | Anti-Aging Pharmacy
Biopharmaceutical Glossaries

Activar - Markets Pero's Cat's Claw Extract AC-11, formerly C-MED-100, for DNA repair.
Advanced Orthomolecular Research | Product Index
All One - Powdered Vitamins and Minerals.
Alta Health Products
American Biotech Labs (Source Naturals) - Silver Biotics. Silver nanoparticle therapy for the immune system.
Annie's Remedy Essential Oils and Herbs.
Anti-Aging Systeme Products include cycloastragenol, astragaloside IV (astragalosides), and astragalus extract.
Argagon Products Sells Secretagogue Gold, containing alpha-glycerylphosphocholine for effective HGH production.
Ayurveda Organics - Ashwaganda, Turmeric, ect.
Barlean's Organic Oils - Flax Oil, Fish Oil, Coconut Oil, Evening Primrose Oil, Borage Oil, and more.
Bell Shark cartilage.
Biochem supplements.
Biotivia Longevity Bioceuticals
Biologix Peptide, cycloastragenol.
- Biospan includes telomerase activator Astragaloside IV, but together with curcumin and silymarin, both telomerase inhibitors.
Bluebonnet supplements. Offers inexpensive ubiquinol CoQ10.
BODYBIO
___Sodium Butyrate [BODY BIO Butyrate Products, Index, Telomerase Activator List, Images, Papers, Patents, Books],
___Sodium-Potassium Butyrate [Images, Papers, Patents, Books].
___Sodium Butyrate upregulates Sp1, which improves the expression of the hTR component of telomerase,
___which is a problem in mesenchymal-derived tissues such as elderly connective tissues and a factor in neck rejuvenation.
___Sodium butyrate inhibits cell growth in colon cancer cells and promotes their elimination [Pat].
___Sodium butyrate, an HDAC inhibitor, improves the size of farm animals.
___Alternate Sodium Butyrate sources:
_____BODYBIO ($24.75/100 caps of 600 mg/cap or 500 mg/cap),
_____T.E.Neesby (($14.08 to $17.60)/100 caps of 550 mg/cap),
_____Shree Ram Enterprises.
_____STEMGENT.
___Alternate Sodium-Potassium Butyrate sources: Bayho
Boericke & Tafel
Brevail - Breast Protection with lignans.
Bronson vitamins and supplements
Centrum vitamins and supplements.
Christopher Wiechert
Continual Youth - Arginine through Resveratrol, ect.
Coromega - Fatty acids supplement.
Country Life.
Convenant Health Products: Brain-Derived Neurotophic Factor [Links].
CrackAging - Cycloastragenol and Astragaloside IV.
Dagoba Organic Chocolate [Google/Dark Chocolate]
DE Vitamins Brain-Derived Neurotrophic Factor [Links]
Dixie Health, Inc, Atlanta, Ga. - Dermal DHEA.
Dynamic Health - Goji Juice, other juices.
Edible Science (Longevity Department) - Specify your own plastic packets of supplement caps and tablets for the day.
Endangered Species Chocolate [Google/Dark chocolate]
emerita - Menopausal skin creams, sexual vitality.
Enzymedica - The Enzyme Experts.
Enzymatic Therapy.
Enzymus Medical - Neprinol for reversing atherosclerosis, Fibrovera for female hormone problems.
Ethical Nutrients.
Extreme Health - Goji Berries [Wikipedia/Wolf Berry].
Flora Premium Herbal Formulas
Forest Herbs - Bioactive New Zealand Herbs.
Futurebiotics - Vitamins, formulas for curing specific ills.
Gaia Chemical Corporation - A wide selection of nutraceutical chemicals for manufacturers, including astragaloside IV.
Gaia Herbs
- Products include Astragalus Root Extract [81s/6b] & other liquid herbal extracts, including astragaloside-specific astragalus extracts, and oxindole-alkaloid specific Cat's Claw extract. Note that CAEs (carboxyl alkyl esters) without oxindole alkaloids present supply the DNA repair and other pharmaceutically active functions in Pero's AC-11 Cat's Claw Extract.
Garden of Life
Garden State Nutritionals - Packages TA-65 into capsules for TA Sciences.
GeniSoy
Peter Gillham's Natural Vitality
Goji Berries - US [Google/Goji Berries]
Green & Black's Organic - dark chocolate varieties.
Green Foods [Products] - Barley grass supplement.
Hain Pure Foods.
Hansen's
Health from the Sun - Essential oils.
Herbal Actives.
Herbalcom's Bulk Herbs with bulk pricing.
Herbal Remedies
HerbaSway
Herbs for Kids
Himalaya Herbal Health Care - Ayurvedic Herbal health care products.
Hodgson Mill - Source of untoasted wheat germ, an element in bone length improvement, if more height is desirable.
Christine Horner, M.D. - Breast protection.
Hyland's Homeopathic Medicines
iHerb - Offers many brands.
International Anti-Aging Systems product list..
Iron-Dragon, cycloastragenol, EGF.
Iron-Tek - Bodybuilding supplements.
Irwin Naturals - Liquid gel vitamins and herbal formulas.
Jarrow Formulas. L-carnosine.
Jason - Pure, Natural, and Organic.
Jay Robbs
KAL supplements. | KAL at Nutraceuticals. L-Carnosine.
King Tiger - Cycloastragenol, astragalus extract, astragalosides.
R.W.Knudsen - Juices
Kroeger Herb.
Kroger pharmacy and health. (Dillons)
Kyo-Green
Kyolic - Aged garlic extract.
Legendary Pharmaceuticals [Home, Founder, Cellular Aging] - Anti-Aging Pharmaceutical & Gene Therapies.
Lewis Labs
LexMD Anti-Aging Supplements, Immune-System Boosters
Liddell Laboratories.
Life Code.
Life Extension product index: Products A-L, Products M-Z.
LifeTIME vitamins. Includes Colostrum (500 mg/cap x 120 caps, 25% Immunoglobins, EGF, $22.99.)
LucsHerb/wolfberries (goji berries) [Google/wolfberries]
Manitoba Harvest - Hemp Foods and Oils.
Maximum Living.
Maxi-Sorb
Michael's Naturopathic Programs - Reishi + Elderberry sold for immune-enhancing effect.
Moducare
Mountain Rose Herbs
NatraBio - Homeopathic tablets.
Natrol.
Naturade
Natural Factors
Natural Immunogenics - Sovereign Silver hydrosol. Silver nanoparticle technique for immune system therapy.
Natural Max.
Nature's Answer - Liquid nutraceuticals. [Astragalus]
Nature's Apothecary
Nature's Bounty (products). Acetyl L-Carnitine with Alpha Lipoic acid.
Nature Made supplements.
Nature's Herbs.
Nature's Life.
Nature's Plus. Glucosamine + Chondritin + MSM for joints.
Nature's Secret
Nature's Way.
____Astragalus Extract ( Standardized 0.5% Astragalosides ), Nature's Way - 60 VCapsules, Astragalus, dried extract 250mg (root) 0.5% astragalosides, with Astragalus (root) 250mg. 4 capsules yield 5 mg astragalosides. See Herbal Remedies.
____Sambucus elderberry - Wikipedia/Sambucus - Antiviral.
Natural Balance.
NaturalCare - Complaint-specific cures.
Natural Factors.
Natural MAX
NeoCell - Collagen, ect.
Newton Homeopathics
NextTag - Distributor. Carries butyrate, a histone deacetylase inhibitor.
New Chapter Organics - Vitamins in probiotics.
Newton Homeopathics
Nordic Naturals fish oils. DHA "brain food".
North American Herb & Spice - Oregano, antioxidant drinks.
Now Foods
____See Now IGF-1 Lozenges for Anti-Aging [Links, NOW], and NOW IGF-1 Lipospray [A1, NOW]
____for sublingual administration (about $25.00 at Whole Foods).
____Also sells Colostrum (Immunoglobins, lactoferrin, EGF, 25% IgG antibodies.)
____An excellent source of the niacinamide (nicotinamide) form of vitamin B3 (Niacin)
____recommended by Kang (Kang, et al., 2006) to improve the cell division limit.
____A fine source of Alpha GPC (alpha glycerylphosphorylcholine),
____an HGH secretagogue and cognitive decline improver.
NuNaturals
Nutraceuticals.
Nutraceutical Sciences Institute GliSODin, other products, via VitaCost.
NutriBiotic - Grapefruit Seed Extract [Wiki] - High levels of vitamin C and E, and bioflavonoids.
Nutricap Labs.
NutriCology.
Nutrition Now
Olay skin care products.
Olympian Labs Incorporated.
OPTIGENEX is the primary source for AC-11 Cat's Claw Extract.
Paradise Herbs
Peptides Store: Bioregulators from Prof. Vladimir Khavinson and the St. Petersburg Institute of Biogerontology.
___For instance, see Endoluten for premature aging, which is where a search for Epithalon Peptide ends up.
___ - Suggestion, editor Koen Langeveld.
Planetary Herbals
Premier Labs
Premier One - Pollen.
Prothera - Markets C-MED-100, Pero's Cat's Claw extract AC-11 for DNA repair.
Pure Essence Labs
Pure Planet
Puritan's Pride - Puritan's Pride Astragalus Extract - good price.
Quantum Health
Rainbow Light.
Ray & Terry's Longevity Products from the authors of Fantastic Voyage.
Ray Sahelian's Supplements, including rare Aryurvedic medicines and many trenchant observations.
Relentless Improvement
Remifemin - Menopause relief.
Renew Life.
RevGenetics : RevGenetics Astragaloside IV (Astral Fruit), Cycloastragenol with Chitosan (Astral Fruit-C).
Rexall. Source of many inexpensive Wal-Mart Pharmaceuticals.
RidgeCrest Herbals
Dr. Al Sears, MD - Telomere support - Telomerase Activation - Dr. Al Sears [Links, Images, Video, Papers, Patents, Books].
____Telomere Secrets - Volume 1.
____Telomere Secrets - Volume 2.
____Telomere Secrets - Volume 3.
____Telomere Secrets - Volume 4.
____Telomere Secrets - Volume 5.
Schiff Vitamins.
Smart Nutrition Pricetam, CDP-Choline, Centrophenoxine, Alzheimer's Drugs, rarieties.
Solaray products, diverse, including astragalus and astragalus extract, and a ginsenoside-specific Korean Ginseng Extract with a Rg1/Rg2 ratio of 0.5. The astragalus root extract product should be analyzed to determine its astragaloside content, which is unknown to us.
Solgar - See Solgar NutrigenomX with GeneLink.
____Solgar NutrigenomX program analyzes genome for SNPs (Single Nucleotide Polymorphisms), supplements accordingly.
____Solgar is a 2nd source for AC-11 Cat's Claw Extract.
Source Naturals, GliSODin, GliSODin Power variants.
Spectrum Essentials.
Spring Valley Herbs and Natural Foods. Found at Wal-Mart.
STARWEST Botanicals - Sources bulk herbs and bulk spices.
Sundown.
Sunny Green
Super Smart nutraceuticals, Super Smart Astragaloside IV.
Suracell - Provides DNA-repair enhancer CAE, an extract from the Tropical Rainforest botanical Uncaria tomentosa, "Cat's Claw" described in The Anti-Aging Solution by Giampapa, Pero, and Zimmerman.
Swanson Vitamins
Tahiti Trader - Noni Juice.
TA Sciences - Manufacturers of TA-65, a telomere-extending astragalus extract. [81s/6b]
T.E.Neesby - T.E.Neesby/Sodium Butyrate. [See also BODYBIO].
___Sodium Butyrate [Index, Telomerase Activator List, Images, Papers, Patents, Books],
___Alternate Sodium Butyrate sources:
_____BODYBIO ($24.75/100 caps of 600 mg/cap or 500 mg/cap),
_____T.E.Neesby (($14.08 to $17.60)/100 caps of 550 mg/cap),
_____Shree Ram Enterprises.
_____STEMGENT.
Telomolecular Corporation - Telomerase activation and telomere extension products. (Corporate Video).
Terraternal Astragaloside IV, Astragaloside IV skin creams, Resveratrol, and many valuable supplements. By April 15, 2011 we also have Terraternal Cycloastragenol at 60 caps x 25 mg/cap for $400.00. This is about the same dose as the most recent papers recommend for TA-65.
TriMedica
Tropical Oasis - Liquid Supplements, Noni Juice, ect.
Twin Labs products. DMAE.
Uni Key Health
VegLife.
Vitamin Research Products
UAS Laboratories.
Udo's Choice.
Vitaspin - Supplements - Vitaspin CT95: Pure Cycloastragenol 5 mg - 30 Caps for $55.99.
Weider supplements.
Weil supplements from Andrew Weil, M.D., author of Healthy Aging, also on DVD.
ZEST for Life vitamin supplements with supplement encyclopedia.
Women's Health - Supplements.
World Organic (RLD Organic)
Wyldewood Cellars - Wichita winery, juices.
Zand Herbal Formulas [Links] - Zand's Astragalus formula contains:
___Astragalus root extract [Images, 81s/TA]
___Codnopsis root "Dong Shen" [Images, Links, Papers]
___Licorice root (root of Glycyrrhiza glabra) [Images, Links]
___Schisandra berry [Images, Links, Books, Papers]
___Ligustrum fruit [Images, Links, Books, Papers]
___Ligusticum wallichi root [Images, Links]
___White peony root [Images, Links]
___Reishi mushroom [Images, Links]

Health Food Stores in Wichita, KS (or anywhere).

Barney's Deep Discount Drugs, 3108 W Central Ave., Wichita, KS 67203,
TEL: (316) 945-9490. Barney's carries sprout bread that can up your SOD levels [64s].
Food For Thought Inc 2929 E Central Wichita, KS 67214-4716 Phone: (316) 683-6078. Carries Food for Life sprout bread.
Green Acres (316) 634-1088, 8141 E. 21st, Wichita, KS. 67206 - (on Map). Carries a fine selection of sprout breads from various vendors.
Wal-Mart, discount drugs and groceries. || Check Drugs & Interactions
Walgreens, another fine source of supplements.
Whole Foods, Central & Woodlawn, 6574 E Central Ave, Wichita - (316) 685-4283

Sprouted Bread Vendors (available at Green Acres)
Alvarado Street Bakery - Sprouted Wheat Bagels, ect.
French Meadow - Sprouted Wheat Raisin & Cinnamon Bagels
Nature's Path - Manna Bread (Sprouted for Life).
Food for Life - Ezekiel 4:9 Sprouted Grain Bread

Bodybuilding Supplements [
Links, Books, Amazon]
Bodybuilding Equipment [Links, Books, Amazon]
Bodybuilding Magazines [Bodybuilding; Links, Directory] | Bodybuilding.com
Flex | Muscle & Fitness [current & past issues] | Iron Man | Muscular Development
USA Powerlifting | Powerlifting USA [Links/Powerlifting, Books/Powerlifting, Links/Olympic Weightlifting]
Exercise Physiology [Links, Books, Amazon]

Astragalus Extract, Astragalus, and Astragalosides [81s/6b], (7), Optimum Anti-Aging Program [Dose].
Google Links: Astragalus [Books], Astragalus Root [Books], Astragalus Root Extract [Books, molecule],
Astragalosides [Books], Astragaloside IV [Books], Cycloastragenol [Books], Astragenol [Books]
A Review of the Pharmacology and Toxicology of Astragalus

Alibaba Bulk astragalus membranaceus root extract, 5kg bags, 25 kg fiber drums, up to 50,000 kg/month AST-1 70% polysaccharide UV, or AST-2 0.3% HPLC astragaloside.
Anti-Aging Systeme Sells cycloastragenol, astragaloside IV (astragalosides), and astragalus extract.
Biologix Peptide, cycloastragenol.
Biopurify:Astragaloside IV. A reader chipped in with a quote for 20 grams of Astragaloside IV by HPLC-ELSD purity > 98% for $980.00 from Biopurify, including shipping by Fedex. Write Haifeng Xie(Mr) 2008-04-07 Add: No.99 Xiaojiaheyanjie, Chengdu, Sichuan, China, 610041, Tel: +86-28-66780410, Fax: +86-28-66042638, Web: www.biopurify.com, MSN:biopurify@hotmail.com.
Biotivia Longevity Bioceuticals - Biospan includes telomerase activator Astragaloside IV, but together with curcumin and silymarin, both telomerase inhibitors.
Calibex Selection of astragalus extracts from different vendors.
Chromadex Reagent-grade Astragaloside IV (Chromadex site)
___ See also Chromadex kits of astragalus saponins, including the astragalosides.
CNCA 15-to-1 Astragalus Root Extract, 300 mg/capsule, 90 capsules/bottle, $21.95/bottle.
At 0.15 mg astragaloside/1000 mg root, a 15-to-1 extract yields 15 x .15 = 2.25 mg/gram astragaloside IV, or 2.25/0.093 = 24.1935 mg total astragalosides. Then 6 capsules yield 1800 mg of extract for 4.05 mg of astragaloside IV, or 43.55 mg of astragalosides. Thus a whole 90 capsule bottle of CNCA astragalus root extract yields 60.75 mg of astragaloside IV, or 653.25 mg of astragalosides.
CrackAging - Cycloastragenol and Astragaloside IV.
Dalton Astragaloside IV.
Dasherb (Herbasin)/astragaloside IV.
Gaia Chemical Corporation - A wide variety of nutraceutical chemicals, including astragaloside IV.
Gaia Herbs
August 9, 2010
GAIA Herbs has reintroduced Astragalus Extract in Glycerin at 30 drops per 1 mg of astragalosides, now delivered with a green flag label. This means that we have a superior product on our hands again for our life extension experiments based on telomerase activation therapy.
- Products include Astragalus Root Extract [81s/6b] & other liquid herbal extracts, including astragaloside-specific astragalus extracts. GAIA Extra Strength Astragalus Extract features 5 mg astragalosides/77 drops, or 1.3 mg astragalosides per 20 drops. Regular GAIA Astragalus Extract contained 1 mg astragalosides/30 drops. Astragalus extract is also available in glycerin from GAIA. See also the large Organic Pharmacy selection of GAIA Astragalus preparations. Only the root is used in GAIA Astragalus Extracts.

October 30, 2008
GAIA Herbs no longer provides astragaloside-specific information on its astragalus extracts according to its company webpage. Formerly, we could obtain GAIA Herbs astragalus extract at 1 mg of astragalosides per 30 drops, or sometimes at 0.5 mg of astragalosides per 30 drops. Now the label claims we get "500 mg of Crude Herb Equivalent" in 30 drops, or words to that effect. (There are 60 drops per teaspoon; 3 teaspoons per tablespoon; 2 tablespoons per fluid ounce.) It is clear that we need web pages from an astragalus extract testing chemistry laboratory that can quantify for us the content of any brand of astragalus extract on the market. It would be useful to know all about the astragaloside content of each available brand of astragalus extract, and about its selenium content and other relevant information. Tests should be periodically rerun for all brands and posted to the net. We have 0.15 mg of astragaloside IV per gram of astragalus root, and GAIA Herbs Astragalus Extract is made from astragalus root only at 500 mg crude equivalent per 30 drops, or 1 gram equivalent per 60 drops, corresponding to 0.15 mg of astragaloside IV per 60 drops, or 0.15/2 = 0.075 mg astragaloside IV per 30 drops. 30 drops typically corresponded to 1 mg astragalosides originally, so that perhaps astragaloside IV/astragalosides = 0.075/1 = 0.075 pertains.
Greenridge Astra Forte as an astragalus extract. (Greenridge, 100 ml per bottle, Price: NZ$28.90, 1000 mg astragalus root equivalant [0.15 mg astragaloside IV equivalent] per 2.5 ml dose, 40 doses per bottle.)
Hangzhou New Asia International [Herbal Extracts, also from 21Food List] Astragalus root extract powder,
_____ AST-1:polysaccharides 70%, AST-2:astragalosides 0.3%.
Herbal Remedies Astragalus 1.25 mg astragalosides per 250 mg cap. Via Nature's Way. Astragalus Extract ( Standardized 0.5% Astragalosides ), Nature's Way - 60 VCapsules, Astragalus, dried extract 250mg (root) 0.5% astragalosides, with Astragalus (root) 250mg. 4 capsules yield 5 mg astragalosides.
Herbasin (Dasherb)/astragaloside IV.
Herb Pharm Astragalus Membranaceus Root Extract, featuring a 1:5 menstruum ratio, Autumn-Harvested. Note that September & October are the best months for Astragalus, according to Xia Q. Ma, Q. Shi, J.A.Duan, Tina T.X.Dong, and Karl W.K.Tsim, Chemical Analysis of Radix Astragali (Huangqi) in China: A Comparison with Its Adulterants and Seasonal Variations, J.Agric.Food Chem., 2002, 50(17), pp 4861-4866.
Herbs for Kids Astragalus Extract.
Honson Astragaloside IV - Packaged as the Pi ce de r sistance. Also see their Astragalus P.E. Series.
"I've been taking astragaloside iv 100mg daily and believe it is working. I no longer have problem with dry eyes... Getting hold of astragaloside iv was hard as could be and took tons of negotiating. 100grams 98% $1500 shipped as of last month." - Andrew (correspondent 1/04/08).
iHerb - List of Astragalus Extract brands with prices.
Iron-Dragon, cycloastragenol.
Jieliang Extract Co., Ltd. [Astragalus Extract] Astragalosides 0.3%,1%,10%,30% by HPLC.
King Tiger - Cycloastragenol, astragalus extract, astragalosides.
MDidea Exporting Division Astragalus Extract powder.
Maximum Telomere Support [Links], 40 mg astragaloside IV and 2000 IU of vitamin D per tablet, recommended dose 2/day, 60 Capsules: $89.95.
Medicass Biotechnologies Astragaloside IV and cycloastragenol.
Nature's Answer - Astragalus Root Extract, 250 mg/cap, 0.3% astragalosides, or 0.75 mg astragalosides/cap.
NutroVita selection of Astragalus products.
Paradise Herbs 12:1 Astragalus Extract 4 caps equivilant to 12 grams astragalus root.
Puritan's Pride - Puritan's Pride Astragalus Extract - good price.
Ray Sahelian Notes on Planetary Formulas Astragalus Extract.
RevGenetics Astragaloside IV (Astral Fruit), Cycloastragenol with Chitosan (Astral Fruit-C).
Solaray Astragalus Root Extract. I initially computed 5 mg of astragalosides per 6 x 200 mg Solaray extract pills. However, only chemical analysis can really determine what the astragaloside content is in this product offering.
I was not able to locate my original calculations on the astragaloside content of Solaray Astragalus Root Extract when I checked after Everett wrote in to ask about it recently, so I took a crack at redoing estimates based on models, rather than a credible chemical analysis, which was unavailable for this product.
Upper Bound
I note that each Solaray pill contains 200 mg of extract, with at least 140 mg that is 70% polysaccharides, according to the description on the bottle. From the paper by M. Du, X.J. Wu cited below on the hairy roots of astragalus membranaceus and the root extract, I note that typically an extract of theirs from roots contains 1.4 mg astragaloside IV per gram of extract, with 30 mg of polysaccharides per gram of extract. If we assume that the astragaloside IV/polysaccharides ratio is about the same in Solaray Astragalus Root extract, Then (1.4/30)x (140 mg extract x 0.7) polysaccharides = 4.57 mg of astragaloside IV per 200 mg pill of Solaray Extract. Then 6 x 4.57 = 27.44 mg of astragaloside IV per 6 Solaray pills, the dose I use. See Astragaloside IV and polysaccharide production by Hairy Roots of Astragalus Membranaceus in Bioreactors by M. Du, X.J. Wu, J. Ding, Z.B.Hu, K.N.White, and C.J.Branford-White in Biotechnology Letters, 25: 2003. My initial calculations used other papers for the ratio of astragalosides to astragalus polysaccharides in ethanol and water astragalus root extracts. This gives you some insight into how the pilot calculation was done from astragaloside/polysaccharide ratios in astragalus root extracts. Of course, their is nothing like checking with quantitative chemical analysis to be sure. - July 8, 2009
Relevant Ratios
Note that from the lifexnotes5.html on high-quality ethanolic extracts from astragalus root, the ratio of astragalosides to total flavones is:
(28 mg astragalosides)/(600 mg flavones) = 0.0467.
On the other hand, from the paper on astragalus membranaceus hairy roots in bioreactors, the ratio of astragaloside IV to total polysaccharides is:
(1.4 mg astragaloside IV)/(30 mg polysaccharides) = 0.4067, the same number!
Other relevant figures for astragalus membranaceus include:
0.15 mg Astragaloside IV/1000 mg of dug out raw root interior = 0.00015.
In a typical extract from astragalus membranaceus done with methanol described in lifexnotes5.html,
(0.8 mg astragaloside IV)/(8.6 mg total astragalosides) = 0.093.
Lower Bound Estimates
If MDidea Exports 0.3% HDLC astragaloside IV astragalus root extract were the same as Solaray,
(0.3/100) x 6 x 200 mg = .3 x 12 mg = 3.6 mg astragaloside IV per 6-cap dose,
or 3.6/0.093 = 38.71 mg astragalosides.
10-to-1 Extract. This is a common astragalus root extract specification ratio.
Then we have 10 x .15 mg astragaloside IV/1000 mg root = 1.5 mg astragaloside IV per gram of extract,
or 1.5/0.093 = 16.13 mg total astragalosides per gram of extract. Then our 6 x 200 mg capsule
dose of Solaray Astragalus Root Extract would yield:
1.5 x 1.2 = 1.8 mg of astragaloside IV and 1.8/0.093 = 19.35 mg total astragalosides.
Thus a 30-pill bottle of 10-to-1 extract at 200 mg/pill would yield 96.75 mg of astragalosides, or 9 mg of astragaloside IV.
Note that the maximum dose of astragalus root used in Chinese medicine corresponded to 33 grams of root, or 33 x 0.15 mg = 4.95 mg of astragaloside IV, or about 4.95/0.093 = 53.23 mg of astragalosides. Geron specified 50 mg to 100 mg of astragaloside IV for treating telomere length in their patent Compositions and Methods for Increasing Telomerase Activity by Calvin B. Harley, et al. (June 1, 2005).
For chemical analysis of Astragalus Membranaceus Root, with regional and seasonal variations in content of astragalosides and polysaccharides, see Xia Q. Ma, Q. Shi, J.A.Duan, Tina T.X.Dong, and Karl W.K.Tsim, Chemical Analysis of Radix Astragali (Huangqi) in China: A Comparison with Its Adulterants and Seasonal Variations, J.Agric.Food Chem., 2002, 50(17), pp 4861-4866, and also see methanolic astragalus extracts in Lifexnotes5.html, which includes more information on minor component astragalosides.
Solgar Astragalus Root Extract 60 caps/bottle, Each vegetable capsule provides: Raw Astragalus Root Powder 250mg, Standardized Astragalus Root Powdered Extract (1mg [0.5%] triterpene glycosides) 225mg.
"Astragalus root contains a series of cycloartane triterpene glycosides denoted astragalosides I-VII (saponins), that are based on the aglycone cycloastragenol and contain from one to three sugars attached at the 3-, 6-, and 25-positions. (5-8) In the predominant astragalosides I-III, the 3-glucose is acetylated." - Astragalus membranaceus - Monograph, Alternative Medicine Review, Feb, 2003.
Sunwaybio Astragaloside IV (Guilin Sanleng Biotech Co.).
Super Smart nutraceuticals, Super Smart Astragaloside IV.
TA Sciences - TA-65, 5 mg/day astragalus-derived telomerase activator, probably cycloastragenol, the common aglycone of the astrogalosides, which is specified at 5 mg/day in the Geron European patent.
Tautobiotech Astragaloside IV
Complete list of Chinese suppliers for Astragaloside IV. [molecule]
Geron obtained astragaloside IV from Ai Chunmei, Chengdu 610041, P.R.China. Note
Institute of Biomedical Engineering, West China Medical Center, Sichuan University, Chengdu 610041, China.
Terraternal Astragaloside IV.
By April 15, 2011 we also have Terraternal Cycloastragenol at 60 caps x 25 mg/cap for $400.00. This is about the same dose as the most recent papers recommend for TA-65. Tradekey Astragaloside IV .

Toxicology of Astragalus
1 pound = 0.45359237 kilograms, 200 lb = 90.718474 kg. See the Lethal Dose definition LD50 in Wikipedia/LD50. No toxic reactions to astragalus in mice at 0.5 g/kg for 30 days, about 45 grams for a 200-lb human. If I assume there are 5 mg of astragalosides per 33 grams of astragalus root, then about 105 drops of GAIA Extra Strength Astragalus Extract, or 6.82 mg of astragalosides, corresponds to the 45 grams of astragalus root. However, this is a lower bound, because 5 mg of astrogalosides per 33 grams of astragalus root applies to the astragaloside IV part of the astragaloside mix only. (0.15 mg astagaloside IV/gram of root x 33 is about 5 mg.) That is, you may take at least 6.82 mg of astragalosides per day (105 drops of GAIA Extra Strength Astragalus Root Extract) with the margin of safety for toxic reactions to astragalus in mice mentioned above. I need to recheck the mg of total astragalosides per gram of astragalus root to get a more accurate figure closer to what you can really tolerate with that margin a safety, probably a somewhat larger dose. Note, however, that this is somewhat more than GAIA Herbs recommends for its regular-strength astragalus root extract, up to 5.33 mg of astragalosides per day [(40 drops x 4)/(30 drops/mg) = 5.33 mg.] In Chinese medicine, 9-30 grams/day is the conventional dose of astragalus root. The LD50 for astragalus in mice was observed to be 39.82 grams/kg. "No detrimental effects in mice were found within 48 hours of oral administration at 75 g/kg or 100 g/kg." "Some evidence shows that doses above 28,000 mg (28 grams or about one ounce [of astragalus root]) per day are no more effective than lower doses. Higher doses may also increase the risk for side effects..." Shen Nong, said to have eaten medicinal plants until he turned green, first discovered astragalus many centuries ago. - from What is Astragalus? Note that telomerase activators such as astragalosides increase the proliferative capacity of cytotoxic (CD8+) T-cells and their ability to produce a virus-fighting molecule, gamma Interferon (IFN(gamma)), which is why astragalus is effective against colds. [article]

December 2, 2008 - Old and New Formulations of GAIA Herbs Astragalus Root Extract
Old and New (degraged) GAIA Herbs Astragalus Root Extract
Left: Old Formula: 1 mg astragalosides per 30 drops.
Right: New Formula: 30 drops per 500 mg crude herb equivalent.
GAIA Herbs may now dilute our medicine to about 1/13 times
its former strength, when it was found to be effective.

The photo on the left shows droppers taken from bottles of old and new formulations of GAIA Herbs Astragalus Root Extract. The darker dropper to the left is rated at 1 mg of astragalosides per 30 drops, while the lighter dropper to the right is rated at 500 mg of crude herb equivalent per 30 drops. Both bottles were priced the same at my local health food store, Whole Foods. I have been using GAIA Herbs extract for telomerase activation for the last 19 months, and seem to have had good results with the old 1 mg of astragalosides per 30 drops formulation, corresponding to a rejuvenation rate of between 7 years per year to 9 years per year, that is, between 358 and 460 base pairs of telomere growth per year. Telomere growth eliminates senescent cells when the telomere t-loops get long enough to close, restoring the cell to the youthful phenotype from the senescent phenotype. The method works on a number of cells, including the adult stem cells that replace melanocytes in hair root follicles. It is also believed to work on dermal fiblasts and many other cells, including microglial cells in the brain that perform clean-up operations that lead to Alzheimer's Disease when these cells fail.
In my experiments here, I have been attempted to use the equivalent of 33 grams of astragalus root per day, the maximum dose of astragalus root used in Chinese medicine. The new formulation described as "500 mg of crude herb equivalent" is thus 1/66 th as strong as I want to use. That is, 66 doses of 30 drops per dose are required to achieve the desired 33 gram dose.
Until recently, I have supposed that 0.15 mg of astragalosides were contained per gram of root, a questionable figure of merit gleaned from textbooks, some which describe this as 0.15 mg of "astragaloside IV", which seems to be wrong. That is, the figure of merit seems from other analysis to apply to the total astragaloside content. Now 33 grams x 0.15 mg/gram = 4.95 mg of astragalosides, about 5 doses of the old GAIA Herbs astragalus root extract at 1 mg astragalosides per 30 drops.
Now the strength ratio of the Old/New = 13.2, since 150 drops/(66 x 30 drops) = 0.07575 = 1/13.2. Evidently, the new formulation supplied by GAIA Herbs may be only about 1/13.2 as strong as the medicine we have been using until this month, so that the cost of equivalent treatment has risen 13.2 times, from $25.50 per month to $336.60.
Unfortunately, I find this out of reach. As far as I know, 1/13 of the dose I want to use might even be beneath the activation threshold for turning on the hTERT gene for production of the DNA repair enzyme telomerase that I want to use to reconstruct my telomeres to cure the senescent condition of my cells. However, it is doubtful that GAIA Herbs, a reputable firm, would provide useless medicine in order to profit. However, in my opinion the new formulation of GAIA Herbs astragalus extract can probably not be used at the same dose with equivalent effect. I feel somewhat like Road Runner temporarily in the clutches of Wiley Coyote in the matter, and hope that GAIA Herbs will universally restore their medicine to its former potency, which is known to have been effective from measurements of grey hair restoration gleaned from inspection of hair clippings. I can presently (Dec.2,2008) buy both "1 mg astragalosides per 30 drops" and "500 mg crude herb equivalent" preparations at Whole Foods, and consider it to be a valuable life-line in the "1 mg astragalosides per 30 drops" incarnation. Of course, there are getting to be more vendors of astragalosides all the time. For instance, consider Terraternal Astragaloside IV.

Astragaloside and Astragaloside IV content of brands - November 19, 2008
I got a letter from Jayne Gale in New Zealand, who was wondering about the utility of Greenridge Astra Forte as an astragalus extract. (Greenridge, 100 ml per bottle, Price: NZ$28.90.) These days 30 drops of GAIA Herbs Astragalus Extract now contain "500 mg of crude herb equivalent" may refer to 30 drops contain the equivalent of 500 mg of crude astragalus herb, which must be the root only, according to Mandy O. Smith of GAIA Herbs. Therefore I would expect 30 drops are equivilant to 500 mg of astragalus root. Since we have typically 0.15 mg "astragaloside IV" per gram of astragalus root, GAIA Herbs astragalus extract must contain about 0.15/2 mg "astragaloside IV" per 30 drops, so that I would typically take 5 times this with 150 drops, or about 5(0.15/2) mg "astragaloside IV", that is about 5(0.15/2) = 0.375 mg "astragaloside IV". A single 2.5 ml dose out of 40 doses of Astra Forte should contain 1000 mg equivilant of astragalus root, 0.15 mg of "astragaloside IV", about 1/2 of the 0.375 mg of "astragaloside IV" I am probably taking from GAIA Herbs Astagalus Root Extract. GAIA Herbs used to claim that 30 drops were equivalent to 1 mg of astragalosides, so that 150 drops were thought to be equivalent to 5 mg of astragalosides. Therefore the "astragaloside IV"/astragalosides ratio would perhaps be 0.375/5 = 0.075. If this were true, then Astra Forte would have 0.15(5/0.375) mg astragalosides per 2.5 ml dose, that is, 0.15(5/0.36125) = 2 mg astragalosides at NZ$28.90 for 40 doses. In other words, you get 40x2 = 80 mg of astragalosides for NZ$28.90, or NZ$0.36125 per mg. In Wichita, 14 5 mg doses of GAIA Herbs Astragalus Extract (2 bottles for 14 x 5 mg = 70 mg astragalosides) costs $25.50, or $0.3643 per mg of astragalosides. (Note the Exchange Rate.)

Figures of Merit for Astragalosides - Nov. 20, 2008.
In high-quality ethanolic extraction [Sup Notes 5], one obtains about 28 mg astragalosides per 100,000 mg of astragalus root, so that
astragalosides/root_material = 28/100,000 = 2.8 x 10-4 grams of astragalosides per gram of root material. Consider the maximum dose of astragalosides used in Chinese medicine, 33 grams. Now 33 for grams of root, 33,000 mg x(2.8 x 10-4 mg astragalosides/mg of root) = 9.24 mg of astragalosides. On the other hand, in a typical ethanolic extraction, we find
(0.15 mg "astragaloside IV"/1000 mg of root)x 33 grams x 1000 mg/gram = 4.95 mg of "astragaloside IV", about 5 mg. This number is of the same order of magnitude as for the high-quality extraction of total astragalosides. However, separation of the astragalosides into their component parts [Sup Notes 5] using a procedure for methanolic extraction makes it clear that "astragaloside IV" must refer to the total quantity of astragalosides in the root, NOT to the quantity of reagent-grade astragaloside IV, which is found in the ratio 0.093, about 1/10, of the total complement of astragalosides. Note 0.093 = 0.8/(0.2 + 3.5 + 0.3 + 2.3 + 1.0 + 0.8 + 0.1 + 0.3 + 0.1) = ratio of reagent-grade astragaloside IV to total astragalosides in a similar methanolic extraction. We are still experiencing problems in interpreting commonly available data regarding figures of merit for ethanol-and-water astragalus extracts such as GAIA Herbs Astragalus Root Extract, now available at "500 mg of crude herb equivalent per 30 drops", which sometimes amounts to "1 mg of astragalosides per 30 drops", and sometimes to "0.5 mg of astragalosides per 30 drops", according to recent prior ratings formerly supplied by GAIA Herbs.

December 13, 2008
In light of the "500 mg crude herb equivalent" specification for GAIA Herbs astragalus root extract, we ask "How much crude astragalus root equivalent is required to supply 1 molecule of astragaloside IV to all 10 trillion cells (1013 cells) in the human body?" The chemical formula for astragaloside IV [MF: C41H68O14 FW: 784.97] is C41H68O14, so that 1 gram-molecular weight of astragaloside IV is approximately 41x12 + 68x1 + 14x16 = 784 grams, corresponding to 784 Daltons, more exactly, 784.97 Daltons. Then
(1013 molecules)/(6 x 1022 molecules per mole)x 784 grams/mole = 1.30667 x 10-9 grams
= 1.3 x 10-6 mg of astragaloside IV. In high-quality ethanolic extraction [Sup Notes 5], one obtains about 28 mg astragalosides per 100,000 mg of astragalus root, so that astragalosides/root_material = 28/100,000 = 2.8 x 10-4 grams of astragalosides per gram of root material. Studies show a ratio of 0.093 parts of astragaloside IV to 1 part of astragalosides. Evidently there are about 2.8x10-4 x 0.093 mg of astragaloside IV per mg of crude herb equivalent, or mg of astragalus root. Thus there are
1.3 x 10-6/(2.8 x 10-4 x 0.093) = 4.9923 x 10-2 mg of root per 10 trillion molecules of astragaloside IV, about 0.05 mg of root. Now 5 droppers full of 500 mg crude herb equivalent will be about 2.5 mg of root/0.05 = 50 molecules/cell available from the stomach. However, only about 2.2% of these make it into the blood, so that we do get about 50 x 0.022 = 1.1 molecules per cell with a 5 dropper dose of 500 mg crude equivalent, assuming 10 trillion cells are to be treated. Our old customary 150 drop (5 dropper) dose using the former GAIA Herbs extract rated at "1 mg astragalosides per 30 drops" , 33 mg of root, is 33 mg root/2.5 mg root = 13.2 times as strong, communicating about 13.2 x 1.1 = 14.52 molecules of astragaloside IV per cell via the bloodstream, remaining in the blood for up to about an hour and a half. Telomerase activation continues for about 24 hours after the initial activation.

November 11, 2008
I get the impression that TA-65 (probably cycloastragenol) is a metabolite of astragalus extracts like GAIA Herbs astragalus extract or TA-41, perhaps produced by HCl in the stomach, so that TA-65 shows up in the blood after astragalus extract is consumed [81s/6c]. This would explain why 5 mg of TA-65 and 5 mg of astragalosides from GAIA Astragalus Extract (when rated at 1 mg astragalosides per 30 drops, and taken at 150 drops) seem to produce very similar results, rejuvenation at a rate of approximately 8 to 9 years per year corresponding to telomere growth of 400 to 460 base pairs of telomere length per year. Of course, we all hope the pure chemical TA-65 will become available as a commercially viable option in the anti-aging medicine selection at health food stores, eventually. In the meantime, TA Sciences has supplied us with some useful data and sources of high-quality measurements, which it makes available as it prepares TA-65 for release. Our own measurements of the utility of astragalus extract based on the color change of grey hair clippings as a function of time are not as precise as the TA Sciences measurements, of course, but I am convinced that off-the-shelf commmercially available astragalus extracts may provide results similar to those obtained using TA-65.

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Your corrections and remarks are welcome. Please write to JimGreenHimself@gmail.com.
Disclaimer: These are student study notes for research on life extension, not the prescription of a medical doctor. These customer investigations of various anti-aging medicines and foods and associated disciplines are not to be interpreted as a medical doctor's prescription or product endorsement. Be sure to check a PDR (Physician's Desktop Reference) regarding dosage, contraindications, and side effects. See also Wal-Mart's checker for Drugs and Drug Interactions and Google Books Pharmaceutical References. It is best to use quality pharmaceuticals from reputable manufacturers according to the instructions of the manufacturer, and to avoid using mere chemicals that may be under investigation for pharmaceutical applications. Many of the tips and clues in this document could benefit from further testing and research.

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