May Day, 2011 Pics at the 4th year of my Experiment | Age Transformation | Index Change Log
Longevity: James A. Green, born 5/13/49. | Cyclic Treatment Time Machine Model | The Time Machine (1960) from George Pal.

May 2007 | Wet & Dry Nov 1, 2009 | Chris Eve 2009 [Detail] Blemishes | March 1, 2010 | April 13, 2010 | May 14, 2010 | August 4, 2010 | Sept 3, 2010
Nov 29, 2010 | Jan 17, 2011 | Feb 28, 2011 | May 1, 2011 | July 5, 2011 | Sept 11, 2011 | Nov 3, 2011 | Jan 10, 2012 | July 17, 2012 | Dec 31, 2012
March 5, 2013 | March 31, 2013 | May 1, 2013 | June 25, 2013 | July 31, 2013 | August 31, 2013 | Sept 30, 2013 | Oct 27, 2013 | Dec 2, 2013
Dec 31, 2013 | Jan 28, 2014 | Feb 28, 2014 | Mar 30, 2014 | May 8, 2014 | May 30, 2014 | July 31, 2014 | Aug 31, 2014 | Sept 20, 2014 | Nov 25, 2014
Jan 2, 2015 | Feb 2, 2015 | Mar 7, 2015

Flashless Photo of The Sleeper. Press for Deaging Lines with Birthdays.
Press for Mom and Dad in fam1.html.
My father James A. Green Jr. (1920-1983)
at 38 with our family dog Puddles in 1958.
Perhaps he was greyer at 38 than I am
at Calendar Age 61.964, Model age 37.22.
Left: May Day, 2011, By the fireplace at Calendar Age: 61.964, Model Age: 37.22, haunted by the ghost of Elizabeth Taylor.
Rejuvenation rate B = - 5.1 years/year. (See Age Transformation.) Next: Sheds 15 pounds to loose 15 years.
Right: My father James A. Green Jr. in 1958 at 38 years of age with the family grape-taster Puddles.
"In normal aging, the onset of hair graying occurs at 34+-9.6 years of age in Caucasians and 43.9+-10.3 years in African Americans, a period in which hair follicles pass though approximately 7-15 complete hair cycles." - Kavita Y. Sarin and Steven E. Artandi (2007), Aging, Graying, and Loss of Melanocyte Stem Cells, Stem Cell Review 3:212-217. Also see E. Wang, MK Artandi, AE Oro, SE Artandi (2005), Conditional telomerase induction causes proliferation of hair follicle stem cells, Nature 436, 1048-1052. See also Siegl-Cachedenier I, Flores I, Klatt P, Blasco MA, Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres. J Cell Biol, 2007 Oct 22;179(2):277-90.

Right: Before Shaving on May 8, 2011. In front of a dinette PC.
Left: Hair on May Day, 2011. My 62nd birthday is May 13, 2011.
Opening the Telomere T-Loop to Improve Telomerase Access
The last few days I've been experimenting with elevating insulin with Fenugreek extract after an exercise session just before bedtime while dosed with several other telomerase-activating substances. The high insulin from Fenugreek extract taken then sweeps sugar out of the blood after a workout, producing a tired, and eventually hungry feeling from hypoglycemia you would not want to suffer while exercising. It helps you go to sleep after a workout, however, and Fenugreek helps with both telomerase activation and telomerase access to the telomere, also restoring muscle tissue glycogen. Before exercising, I used 10 grams of L-arginine to elevate nitric oxide (NO) levels, which activates telomerase in vascular endothelial cells, along with 2 grams of L-lysine. The combination of L-arginine and L-lysine increases expression of HGH, which is telomerase-activating. In addition, I took sweetened rosemary tea to elevate Nerve Growth Factor levels, which elevates the expression of Id-1 helix-loop-helix transcription factor [List], which acts on the hTERT gene to promote the transcription of the catalytic component of telomerase (hTERT protein). In addition, I took a big dose of astragalus extract amounting to perhaps 10 or 15 mg of astragalosides, and rubbed in roughly 10 mg of cycloastragenol in a transdermal cream. I also took Forskolin before the workout to elevate testosterone, which has telomerase-elevating effect in heart muscle tissues, skeletal muscles, and melanocytes that color hair. The Fenugreek extract elevates testosterone after the workout, and also supplies diosgenin for telomerase activation by promoting the expression of the transcription factor HIF-1, together with 4-hydroxyisoleucine that elevates insulin to phosphorylate tankyrase 1, which opens telomere t-loops to access by the telomerase holoenzyme. I had also taken 2-3 grams of niacinamide (nicotinamide), which provides a NAD+ substrate for the poly(ADP-ribosylation) reaction that strips telomere t-loop closure protein TRF1 from the telomere, allowing it to open for access by telomerase.
I am not rubbing Fenugreek alcohol extract over my chest, which would produce the breasted look within 8 weeks. I wonder if such an extract with its Fenugreek saponins might not be useful for the scalp and hair follicles. Just taking Fenugreek extract orally before bedtime does not typically produce a breasted transformation in 2 weeks, and I propose to try cycling Fenugreek with my telomerase activators (2 weeks on, then 2 weeks telomerase inhibitors) in order to improve the bioavailability of telomerase at the telomere for my rejuvenation application. It takes 4-8 weeks to produce breast enlargement in women at a dose of about 3 grams of Fenugreek seeds/day, which costs < $9 per pound. However, this is preceeded by a tingly feeling, so that you can detect when it is starting to impact cellular differentiation in tissue and quit. The high insulin from the Fenugreek 4-hydroxyisoleucine tends to boost appetite, and is used to fatten up farm animals. High insulin can make you feel apple-cheeked by socking blood sugar into your cheeks, which I am trying to compensate for by using more fiber during the day and less meat and fish.

Dame Elizabeth Taylor was in great shape at 60 for a starting over at 60 photo.
She was interested in Life Extension research, and would have gladly served as the new Jeanne Calment [Photo Gallery].

Press for images of Elizabeth Taylor at 60. Actually, says Liz, I'm The Lady from 365.25x60 = 21,915 Revolutions, a bigger draw than The Beast from 20,000 Fathoms.
Press for family photos at fam6.html.
With grandfather James A. Green Sr.
(1890-1973), shown at age 59 in 1949.

Press for The Time Machine (1960) from George Pal. Press for TA Sciences.
Liz Taylor Wins with Life Extension Technique and Anti-Aging Makeup Expertise,
Haunting with Electric Clarity from the 5th dimension in etherial movie frames,

LOOking like the Cat's Meow I'd rather have heard. Study, then ride heady pills into the future.
Music: Me and Julio Down by Schoolyard by Paul Simon or A Summer Song by Chad & Jeremy.
The Pretty Little Surey with The Fringe on the Top - An old favorite of my Grandfather Green.

April 2011 Life Extension Program with New Insights for May

Cycloastragenol and Astragalus Extract for Primary Telomerase Activation
In April 2011 I used experimenter's cycloastragenol (10 mg/day) from a chemical supply company for the rejuvenation application for the first 15 days of the month, plus a couple of bottles of GAIA Herbs astragalus root extract in glycerin (green label, 1 mg astragalosides per 30 drops), which I applied to my scalp. I tried to put the cycloastragenol in via a transdermal route of application scheme.

Forskolin for Hair Darkening Improvements
I started taking Forskolin to darken my hair toward the end of the month, after I read that Forskolin darkens hair, and upgraded my Hair Greying index entry on the topic.

Thymic Restoration with Telomerase Activation from Nitric Oxide
This April 2011 I used 10 grams of arginine per day during the first 15 days of the month in order to stimulate the thymus gland, restore youthful levels of thymic hormones, and rejuvenate endothelial progenitor cells.

Confining High Vitamin D to Telomerase Inhibition Periods
Otherwise, I followed the routine from the prior month, except that I used high vitamin D levels only during the final 15-day telomerase inhibition periods, as I confirmed in February that Vitamin D3 is a telomerase inhibitor.

Nicotinamide to Impove the Hayflick Limit
I tried again to follow Kang's advice on nicotinamide [Links], which has extended life spans of cells in the lab by a factor of 1.6. (See Kang HT, Lee HI, Hwang ES (2006), Nicotinamide extends replicative lifespan of Human Cells, Aging Cell, 5(5): 423-36.) This is due to fewer telomeric repeats lost per cell division, so that cells can divide more. This month I could obtain 500 mg capsules of Now Foods nicotinamide (niacinamide, a form of niacin, also a form of Vitamin B3), which I added to my usual 4 daily Super B-Complex pills including 100 mg of niacinamide [Links, also called nicotinamide], in addition to other B-vitamins and material functioning like a homocysteine shield against atherosclerotic plaque. I took the nicotinamide recommended by Kang, 500 mg in the morning and 500 mg before bedtime.

Nicotinamide to Increase Tankyrase Expression and NAD+ levels for opening T-Loops
I note that my recent research shows that niacinamide can be taken < 3 grams/day (while taking a telomerase activator) to provide the NAD+ substrate required by tankyrase 1 to strip TRF1 telomere binding protein with poly(ADP-ribosylation), opening telomere loops for telomerase access and subsequent extension of the telomere. Alternatively, NAD can be taken directly as a supplement to enhance TRF1 t-loop closure protein stripping. Furthermore, insulin boosters such as 4-hydroxyisoleucine [Images] can be used at the end of a workout to phosphorylate tankyrase 1, making it active for this reaction. Furthermore, tankyrase 1 expression is known to be enhanced by niacinamide, so that in May for the first time I will be consciously opening telomere loops with tankyrase 1 before acting on them with telomerase expressed via the upregulation of hTERT mRNA levels using small molecule telomerase activators.

Boosting HGH levels for growth hormone telomerase activation
I also used whey protein, another HGH secretagogue added to arginine to kick HGH up as high as possible to get higher hTERT mRNA levels to support telomerase activity (7). However, unless I get behind heavier iron, nothing much will happen to my physical size from doing pushups, curls with light dumbells, and other light exercise, although my HGH levels are high. I had to do 35 pull-ups with 100 lb chained on to get 19 inch arms back when I was really doing some bodybuilding. Creatine monohydrate could usually get me through sticking points, which is how I pressed 300 lb at 48. Caloric restriction, however, ought to eventually produce a leaner, more photogenic look. I don't know why I find caloric restriction such a devilish challenge.

Telomerase Activation On Period (1st 15 days of the month)
10 mg/day Cycloastragenol per day (10 mg in skin cream at bedtime),
____[but preferably 25 mg of cycloastragenol or TA-65 orally]),
4 mg astragalosides/day to the scalp as a telomerase activator,
____GAIA Herbs Astragalus Root Extract, 30 drops per 1 mg astragalosides.
10 grams arginine as an HGH secretagogue and telomerase activator via Nitric Oxide.
Whey protein as an HGH secretagogue. HGH activates hTERT mRNA transcription.
Rosemary, including Rosemary tea (extract) and Essential Oil of Rosemary nasal inhalent.
Niacinamide < 3 grams (Now Foods), to enable tankyrase 1 t-loop cracking
____and improve the Hayflick cell division limit (Kang, et al, 2006).
Forskolin to improve testosterone for telomerase activation in androgen-dependent cells
____such as heart stem cells, muscle stem cells, and hair folicle melanocytes.
Low-Polyphenol diet (tuna, skim milk, grapefruit, pineapple).

Every Day of the Month
1 or 2 Equate multivitamin pills.
3000 mg of vitamin C/day, 500 mg per serving, distributed over the day.
500 mg x 2 of Nicotinamide (Niacinamide)/day (Now Foods niacinamide).
100 mg Qunol Ultra CoQ10/day (a Wal-Mart brand claiming x 3 bioavailability),
4 x (200 mg alpha lipoic acid + 400 mg Acetyl L-Carnitine) Spring Valley.
4 x Acetyl L-Carnitine) Super B-Complex tablets, Spring Valley.
____4 x (150 mg vitamin C, 100 mg vitamin B1, 20 mg vitamin B2, 25 mg niacinamide,
____2 mg vitamin B6, 400 mcg Folic Acid, 15 mcg vitamin B12, 3.8 mcg Biotin,
____5 mg Pantothenic acid, Liver powder 100 mg, Brewer's Yeast 100 mg.)
4 x 400 mg Magnesium, with 15 mg zinc (15 mcg vitamin B12, 3.8 mcg Spring Valley).

Telomerase Inhibition Period (Last 15 days of the month)
4 x 2000 IU, vitamin D3, Super Strength, Spring Valley.
Green Tea every day to the scalp as a dihydrotestosterone inhibitor, foils hair loss.
3 x 2 tablespoons Coca powder in ice water, taken like tea.
4 x Green Tea Tablets (EGCG 60 mg, chromium 100 mcg, apple cider vinegar 500 mg,
____Citrus Aurantium 300 mg).
8 x 200 mg Red Wine Complex (contains Resveratrol), Spring Valley.
4 x 1000 mg Omega-3 Fish Oil, Spring Valley.
1 x 3 mg Melatonin (Spring Valley Tablet) at bedtime.
Curcumin from Turmeric, taken in water with black pepper to improve bioavailability.
High-Polyphenol diet (tends to generate anticancer telomerase inhibitors).

George Washington 40, 1772.

George Washington 63, 1795.
Press for Jeanne Calment photo album.Press for Jeanne Calment photo album.
Left Jeanne Calment, age 25. Right Jeanne Calment, age 60.
Jeanne Calment is the world record holder in aging at 122.45 years.
Press for larger photo.Press for larger photo.
Left Jim Green (58), May 2007. Right Jim Green (61.964, Model Age: 37.22), May 1, 2011.
Old Side Story: Still a little too heavy to be as photogenic as possible.
I look my best when I'm crystalline-lean. [Previous | Next]

Albert Einstein at 26.Einstein at 61 gets citizenship.
Left Albert Einstein, age 26. Right Albert Einstein at age 62 plays violin.
Einstein passed away at 76 in 1955, igniting a dramatic radio report I heard as a child.
See Einstein's Greying Rise Time.

Above: J. Robert Oppenheimer [April 22, 1904 - February 18, 1967 (aged 62)].

Anti-Aging Flight Plan down to Model Age 25.12 on August 31, 2013 at Age 64.3.
Here Model_Age = Bt + Starting_Age, B=1 for normal aging, B > 1 for accelerated aging,
B=0 for no aging, and B < 0 for rejuvenation, or negative aging. Here initially B= 1 for
normal aging, then B= - 5.2 years/ year during the deaging phase, followed by B=0 zero aging
until Madame Jean Louise Calment's 122 years, 164 days record is exceeded at 2071.9634 AD,
which should be right at the Winter Solstice when shadows are shortest about Dec 22, 2071.
About this time the S.Monocerotis skywalker above the Cone Nebula crosses the meridian.

Note the "Cross of Years" formed by the 110 and 122.45 barriers. There are thousands
of Americans over 100, of whom hardly any will get though the 110 year barrier without medicine.

Longevity. Music: Silver Thunderbird and Walking in Memphis by Marc Cohn.

"If the radiance of a thousand suns
Were to burst at once into the sky,
That would be like the splendor
Of the Enlightened One..."

- from The Bagavid Gita, also quoted by J. Robert Oppenheimer.

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May 2007 | Wet & Dry Nov 1, 2009 | Chris Eve 2009 [Detail] Blemishes | March 1, 2010 | April 13, 2010 | May 14, 2010 | August 4, 2010 | Sept 3, 2010
Nov 29, 2010 | Jan 17, 2011 | Feb 28, 2011 | May Day, 2011 | July 5, 2011 | Sept 11, 2011 | Nov 3, 2011 | January 10, 2012 | July 17, 2012 | Dec 31, 2012
March 5, 2013 | March 31, 2013 | May 1, 2013 | June 25, 2013 | July 31, 2013 | August 31, 2013 | Sept 30, 2013 | Oct 27, 2013 | Dec 2, 2013
Dec 31, 2013 | Jan 28, 2014 | Feb 28, 2014 | Mar 30, 2014 | May 8, 2014 | May 30, 2014 | July 31, 2014 | Aug 31, 2014 | Sept 20, 2014 | Nov 25, 2014
Jan 2, 2015 | Feb 2, 2015 | Mar 7, 2015

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