July 17, 2012 Pics early in the 6th year of my Experiment. Model Age 30. | Age Transformation | Index Change Log
Longevity: James A. Green, born 5/13/49. | Cyclic Treatment Time Machine Model | The Time Machine (1960) from George Pal.

May 2007 | Wet & Dry Nov 1, 2009 | Chris Eve 2009 [Detail] Blemishes | March 1, 2010 | April 13, 2010 | May 14, 2010 | August 4, 2010 | Sept 3, 2010
Nov 29, 2010 | Jan 17, 2011 | Feb 28, 2011 | May 1, 2011 | July 5 2011 | Sept 11, 2011 | Nov 3, 2011 | January 10-22, 2012 | July 17, 2012 | Dec 31, 2012
March 5, 2013 | March 31, 2013 | May 1, 2013 | June 25, 2013 | July 31, 2013 | August 31, 2013 | Sept 30, 2013 | Oct 27, 2013 | Dec 2, 2013
Dec 31, 2013 | Jan 28, 2014 | Feb 28, 2014 | Mar 30, 2014 | May 8, 2014 | May 30, 2014 | July 31, 2014 | Aug 31, 2014 | Sept 20, 2014 | Nov 25, 2014
Jan 2, 2015 | Feb 2, 2015 | Mar 7, 2015

< Press for deaging chart. Calendar Age = 63.178, Model Age = 30.932.
Left: July 17, 2012, Calendar Age: 63.178, Math Model Age: 30.932.
Right: Calendar Age 63.750 from Frame second 30 of 85 years in 40 Seconds, below.

Frame secondAge (years)

85 years in 40 seconds.

Telomerase Activators.

90 Years Old in Less Than 3 Minutes (3 yr old to 90 yr old)
My Father's Generation.
1922(3), 1929(10), 1935(16), 1938(19), 1942(23), 1947(28), 1953(34), 1962(43),
1973(54), 1985(66), 1994(75), 2002(83), 2006(87), 2007(88), 2008(89), 2009(90).

Telomere Length Counter and Corresponding Portraits:

Telomeres and Aging (Full Length)
with Dr. Bill Andrews.

Medicines and Dosages: Revised July 22, 2012

At this time my approach here is to use a number of telomerase activators [List] in parallel as I attempt to meet the original goals. Twelve endogenous telomerase activators from exercise may be amplified with specific secretagoge supplements, and I am still using astragalus extracts and astragalosides, in addition to Fenugreek extract, ginkgo biloba ginkgolides, and nitric oxide boosters. The mainstay of the 2-week telomerase activation phase in July 2012 was astragalus root at 25 to 33 grams/day, astragalus extract for the scalp (5 droppers/day of 30 drops/milligram of astragalosides), with 4 x (175 mg/cap) capsules/day of black cohosh extract taken orally, 3.25 grams/day of Fenugreek extract (5 x 620 mg taken orally before bedtime) for diosgenin and HIF-1 transcriptional activation of hTERT, colostrum taken orally (4 x 500 mg/day) and as a skin cream (3 x 500 mg/day in water), arginine (8 to 10 grams/day) for nitric oxide telomerase activation in endothelial progenitor cells, DHEA (4 x 25 mg/day) for testosterone [List], Alpha GPC (1-2 grams/day) for supplemental HGH activation of hTERT, and ginkgo biloba (4 grams/day) for HIF-1 hTERT transcriptional activation. In addition, I used moderate exercise and associated supplements including arginine and alpha-GPC to boost the 12 exercise-induced telomerase activators.

2012 Life Extension Program with New Insights for January 2012, plus July 2012

In January 2012 I used astragalus extract on my scalp again, but added tribulus, which promotes the expression of melanocyte-stimulating hormone, and took ashwagandha, which elevates endogenous antioxidants including catalase. (In July 2012 I substituted bacopa for ashwagandha, which also boosts the endogenous antioxidants. However, bacopa elevates thyroid hormone T4, and I took it 1-2 grams with meals for a while to improve my leanness. Furthermore, some vendors now claim that bacopa is a telomerase activator, although this is not now well documented in publicly available scientific studies.) Catalase is believed to inhibit the bleaching of hair from the inside out with endogenous hydrogen peroxide. Melanocyte-stimulating hormone is believed to darken hair. Instead of applying Sequel Rejuvenating Colostrum Skin Cream, I mixed up a slurry of bovine colostrum in water and rubbed it in like a skin cream. Colostrum contains TGF-beta, a telomerase inhibitor that reconstructs the extracellular matrix including both collagen and elastin. It also contains many other telomerase-activating growth factors found in growth factor skin creams including TGF-alpha, EGF, IGF-1, IGF-2, VEGF, FGF, and PDGF. In addition to mixing NOW Colostrum (powdered) with water to apply it as a skin cream, I have also tried mixing it in olive oil, in which colostrum is not soluble, however. Both formulae may be useful, but the solubility of colostrum in water makes the aqueous formulation most attractive. Perhaps a paste of powdered colostrum and water would be effective applied as a mask. Colostrum water may be helpful applied to the scalp.

2011 Recommended Life Extension Program with July 2012

I was formerly sometimes using bacopa to upregulate endogenous antioxidants including SOD, catalase, and glutathione peroxidase, before reading that some vendors claim bacopa as a telomerase activator. In June 2011 I used ashwagandha [withania somnifera] to upregulate SOD, catalase, and glutathione, relying on melatonin to upregulate glutathione peroxidase during the last half of the month. Catalase upregulation should be useful to oppose hair greying.

For telomerase upregulation I took 25 g of astragalus root/day with astragalus extract including 10 mg of astragalosides. I upregulated nerve growth factor with acetyl L-carnitine (4 x 400 mg) and alpha lipoic acid (4 x 200 mg), which upregulates Id-1 helix-loop-helix transcription factor, which upregulates the production of hTERT mRNA. In addition, I took rosemary tea, which also upregulates nerve growth factor and Id-1. To activate telomerase in endothelial progenitor cells I took Ginkgo Biloba (1.5 grams/dose x 4 doses), which upregulates HIF-1 transcription factor, and L-arginine (10 grams), which upregulates Nitric Oxide. HGH was upregulated with whey protein and 1.5 grams of arginine plus 1.5 grams of leucine. In July 2012 I used alpha-GPC as an HGH secretagogue for boosting hTERT mRNA levels with HGH. After evening exercise, I took 620 mg x 5 = 3.25 grams of Fenugreek extract to upregulate insulin and phosphorylate tankyrase 1 to remove the TRF1 loop closure protein to open telomere t-loops for access by the telomerase holoenzyme. Fenugreek also upregulates testosterone, a telomerase activator in for cardiac cells, muscles and melanocytes, and provides diogenin, another HIF-1 transcription factor upregulator. At this low dose, no undesired transformations are expected from Fenugreek phytoestrogens when the application period is just two weeks.

April 2011 program with upgrades for July 2012

Cycloastragenol and Astragalus Extract for Primary Telomerase Activation
In April 2011 I used experimenter's cycloastragenol (10 mg/day) from a chemical supply company for the rejuvenation application for the first 15 days of the month, plus a couple of bottles of GAIA Herbs astragalus root extract in glycerin (green label, 1 mg astragalosides per 30 drops), which I applied to my scalp. I tried in 2011 to put the cycloastragenol in via a transdermal route of application scheme. By July 2012 I concluded from studies done by the VIDA Institute, Terraternal, and Calvin B. Harley, et al., that astragalus root at 25-33 grams/day would be more effective than cycloastragenol (25 mg/day), TA-65 (25 mg/day), or astragaloside IV (100 mg/day) for lengthening telomeres to obtain rejuvenation effects. I tried shelling astragalus root powder out of gelatin capsules, mixing it as a suspension in water, and heating it up to be served as a tea with sweetener. Although you have to stir the mixture with a spoon because it somewhat settles out of solution, this is easier than swallowing 66 x 500 mg capsules throughout the day.

Forskolin & Tribulus for Hair Darkening Improvements
I started taking Forskolin to darken my hair toward the end of the month in 2011, after I read that Forskolin darkens hair, and upgraded my Hair Greying index entry on the topic. Forskolin also elevates the expression of testosterone, which promotes reverse cholesterol transport and activates telomerase in muscle tissues and hair follicles via the androgen receptor. Tribulus, an aphrodisiac, also darkens hair by increasing the expression of melanocyte-stimulating hormone.

Thymic Restoration with Telomerase Activation from Nitric Oxide
In April 2011 and July 2012 I used 10 grams of arginine per day during the first 15 days of the month in order to stimulate the thymus gland, restore youthful levels of thymic hormones, and rejuvenate endothelial progenitor cells.

Confining High Vitamin D to Telomerase Inhibition Periods
Otherwise, I followed the routine from the prior month, except that I used high vitamin D levels only during the final 15-day telomerase inhibition periods, as I confirmed in February that Vitamin D3 is a telomerase inhibitor.

Nicotinamide to Improve the Hayflick Limit
I tried again to follow Kang's advice on nicotinamide [Links], which has extended life spans of cells in the lab by a factor of 1.6. (See Kang HT, Lee HI, Hwang ES (2006), Nicotinamide extends replicative lifespan of Human Cells, Aging Cell, 5(5): 423-36.) This is due to fewer telomeric repeats lost per cell division, so that cells can divide more. In April 2011 I could obtain 500 mg capsules of Now Foods nicotinamide (niacinamide, a form of niacin, also a form of Vitamin B3), which I added to my usual 4 daily Super B-Complex pills including 100 mg of niacinamide [Links, also called nicotinamide], in addition to other B-vitamins and material functioning like a homocysteine shield against atherosclerotic plaque. I took the nicotinamide recommended by Kang, 500 mg in the morning and 500 mg before bedtime.

Nicotinamide to Increase Tankyrase Expression and NAD+ levels for opening T-Loops
I note that my recent research shows that niacinamide can be taken < 3 grams/day (while taking a telomerase activator) to provide the NAD+ substrate required by tankyrase 1 to strip TRF1 telomere binding protein with poly(ADP-ribosylation), opening telomere loops for telomerase access and subsequent extension of the telomere. Alternatively, NAD can be taken directly as a supplement to enhance TRF1 t-loop closure protein stripping. Furthermore, insulin boosters such as 4-hydroxyisoleucine [Images] can be used at the end of a workout to phosphorylate tankyrase 1, making it active for this reaction. Furthermore, tankyrase 1 expression is known to be enhanced by niacinamide, so that in May for the first time I will be consciously opening telomere loops with tankyrase 1 before acting on them with telomerase expressed via the upregulation of hTERT mRNA levels using small molecule telomerase activators.

Boosting HGH levels for growth hormone telomerase activation
I also used whey protein, another HGH secretagogue added to arginine to kick HGH up as high as possible to get higher hTERT mRNA levels to support telomerase activity (7). However, unless I get behind heavier iron, nothing much will happen to my physical size from doing pushups, curls with light dumbells, and other light exercise, although my HGH levels are high. Creatine monohydrate is actually more anabolic than whey protein for supporting muscle growth and avoiding old age sarcopenia. I had to do 35 pull-ups with 100 lb chained on to get 19 inch arms back when I was really doing some bodybuilding. Creatine monohydrate could usually get me through sticking points, which is how I pressed 300 lb at 48. Creatine monohydrate also elevates IGF-1 levels and lead to 10% - 12% longer lifetime in experimental animals. Caloric restriction, however, ought to eventually produce a leaner, more photogenic look. I don't know why I find caloric restriction such a devilish challenge.

Telomerase Activation On Period (1st 15 days of the month)
25-33 grams/day NOW astragalus root, mixed with water and served as a tea with sweetener.
____Formerly 10 mg/day cycloastragenol per day (10 mg in skin cream at bedtime),
____[but preferably 25 mg of cycloastragenol or TA-65 orally]),
4 mg astragalosides/day to the scalp from astragalus extract as a telomerase activator,
____GAIA Herbs Astragalus Root Extract, 30 drops per 1 mg astragalosides.
4 x (175 mg/cap) capsules/day of black cohosh extract taken orally.
3.25 grams/day of Fenugreek extract (5 x 620 mg taken orally before bedtime)
____for diosgenin and HIF-1-mediated transcription of hTERT mRNA.
____Also provides insulin to phosphorylate tankyrase 1 for opening telomere t-loops
____with TRF1 protein stripping.
Ginkgo biloba (4 grams/day) for HIF-1-mediated transcription of hTERT mRNA.
Colostrum taken orally (4 x 500 mg/day) and as a skin cream (3 x 500 mg/day in water).
____Colostrum transcribes hTERT mRNA, Phosphorylates hTERT, uses the MAPK pathway,
____and contains telomerase activators IGF-1, IGF-2, EGF, TNF-alpha,
____FGF, PDGF, VEGF, and TGF-alpha.
DHEA (4 x 25 mg/day) for telomerase-activating testosterone [List],
Forskolin to improve testosterone for telomerase activation in androgen-dependent cells
____such as heart stem cells, muscle stem cells, and hair folicle melanocytes.
Alpha GPC (1-2 grams/day) for supplemental HGH-mediated transcription of hTERT mRNA, and
10 grams arginine as an HGH secretagogue and telomerase activator via Nitric Oxide.
Whey protein as an HGH secretagogue.
____HGH activates transcription of hTERT mRNA.
Creatine monohydrate to elevate levels of telomerase activator IGF-1,
____which phosphorylates cytoplasmic hTERT protein for import into the nucleus.
Rosemary, including Rosemary tea (extract) and Essential Oil of Rosemary nasal inhalent,
____to elevate Nerve Growth Factor and levels of ID-1 helix-loop-helix transcription factor.
Niacinamide < 3 grams (NOW Foods), to enable tankyrase 1 t-loop cracking
____and improve the Hayflick cell division limit (Kang, et al, 2006).
Low-Polyphenol diet (tuna, skim milk, grapefruit, pineapple).

Every Day of the Month
1 or 2 Equate multivitamin pills.
3000 mg of vitamin C/day, 500 mg per serving, distributed over the day.
500 mg x 2 of Nicotinamide (Niacinamide)/day (NOW Foods niacinamide).
4 x 100 mg Qunol Ultra CoQ10/day (a Wal-Mart brand claiming x 3 bioavailability),
___because CoQ10 is required to reduce lipofuscin and improves lab animal lifetimes 20%.
___More CoQ10 would be safer, although it is costly. By 2012 I take 4x what I took in 2011.
4 x (200 mg alpha lipoic acid + 400 mg Acetyl L-Carnitine) Spring Valley.
4 x Acetyl L-Carnitine) Super B-Complex tablets, Spring Valley.
____4 x (150 mg vitamin C, 100 mg vitamin B1, 20 mg vitamin B2, 25 mg niacinamide,
____2 mg vitamin B6, 400 mcg Folic Acid, 15 mcg vitamin B12, 3.8 mcg Biotin,
____5 mg Pantothenic acid, Liver powder 100 mg, Brewer's Yeast 100 mg.)
4 x 400 mg Magnesium, with 15 mg zinc (15 mcg vitamin B12, 3.8 mcg Spring Valley).
__Magnesium L-Threonate 2000 mg/day, is superior to magnesium for synapse rejuvenation.
Get vitamin K2 from supplements, hard cheeses or select vegetables to deflect tissue calcification.
A walnut/day for alpha lineolic acid and lineolic acid, essential fatty acids.
Pump up with exercise using a split routine to cover the body in 3 to 4 days.
__Keep sugar low to avoid sugar glycation leading to arteriosclerosis
__that threatens elderly ice cream eating exercisers with a subclavian anuerysm.
__A lean gymnastic physique is good for longevity and elderly morale, often puts 20 years on.
Brush and floss your teeth frequently, bleach from time to time. See dental.html.
Do under-the-chin platysma muscle exercises for neck rejuvenation.
Use Compound W Freeze-Off to remove skin lesions and touch up your skin.
Use mild heat stress (sauna, sweat suits) periodically (1 hr 2 x per week) for hormesis benefits.

Telomerase Inhibition Period (Last 15 days of the month)
4 x 2000 IU, vitamin D3, Super Strength, Spring Valley.
Green Tea every day to the scalp as a dihydrotestosterone inhibitor, foils hair loss.
Milk Thistle, 4 capsules/day, for silymarin. (by July 2012.)
3 x 2 tablespoons Coca powder in ice water, taken like tea.
4 x Green Tea Tablets (EGCG 60 mg, chromium 100 mcg, apple cider vinegar 500 mg,
____Citrus Aurantium 300 mg).
8 x 200 mg Red Wine Complex (contains Resveratrol), Spring Valley.
4 x 1000 mg Omega-3 Fish Oil, Spring Valley.
1 x 3 mg Melatonin (Spring Valley Tablet) at bedtime.
Curcumin from Turmeric, taken in water with black pepper to improve bioavailability.
High-Polyphenol diet (tends to generate anticancer telomerase inhibitors).

P16/Rb Inhibition
Carrots may taken daily to improve P16INK4A inhibition from retinol conversion to retinoic acid and to provide more retinoic acid obtained from beta carotene. Substantial daily bodybuilding exercise will further inhibit P16INK4A, promote exercise-induced telomerase activators for telomere maintenance, lower the LDL/HDL cholesterol ratio, improve lipid profiles, and elevate testosterone for reverse cholesterol transport to oppose the development of atherosclerotic plaque.

Costs seem to range between $110 to $200 dollars per month from discount drug stores and health food stores when astragalus root powder is the mainstay of the program. Ideally, a more expensive program reduces the amount of pill swallowing to be endured.

George Washington 40, 1772.

George Washington 63, 1795.
Press for Jeanne Calment photo album.Press for Jeanne Calment photo album.
Left Jeanne Calment, age 25. Right Jeanne Calment, age 60.
Jeanne Calment is the world record holder in aging at 122.45 years.
Press for Judy Collins at 62.
Press for larger photo.Press for larger photo.
Left Jim Green (58), May 2007. Right Jim Green (63.178, Math Model Age: 30.932), July 17, 2012.
In reality, Green's neck has improved. [Previous | Next]
From test photos, I'd say I seem to be unsmiling because I have minor dental flaws I forget about that do require correction. I had to twist a front tooth to make it come in right as a child, and in some photos the shades make it seem to be a snaggle tooth after all. I had better see to carefully correcting everything in the dentition to emerge with a victorious grin. I unconsciously cover for it by not smiling much. Furthermore, I need to fully restore my 2nd maxillary premolars. More medicines would also help, so I need to cultivate better financial habits, now that effective solutions have been identified.

Albert Einstein at 26.Einstein at 61 gets citizenship.
Left Albert Einstein [Links], age 26. Right Albert Einstein [Images] at age 62 plays violin.
Einstein passed away at 76 in 1955, igniting a dramatic radio report I heard as a child.
See Einstein's Greying Rise Time.

Above: J. Robert Oppenheimer [April 22, 1904 - February 18, 1967 (aged 62)].

Anti-Aging Flight Plan down to Model Age 25.12 on August 31, 2013 at Age 64.3.
Here Model_Age = Bt + Starting_Age, B=1 for normal aging, B > 1 for accelerated aging,
B=0 for no aging, and B < 0 for rejuvenation, or negative aging. Here initially B= 1 for
normal aging, then B= - 5.2 years/ year during the deaging phase, followed by B=0 zero aging
until Madame Jean Louise Calment's 122 years, 164 days record is exceeded at 2071.9634 AD,
which should be right at the Winter Solstice when shadows are shortest about Dec 22, 2071.
About this time the S.Monocerotis skywalker above the Cone Nebula crosses the meridian.

Note the "Cross of Years" formed by the 110 and 122.45 barriers. There are thousands
of Americans over 100, of whom hardly any will get though the 110 year barrier without medicine.

Press for Mortality Charts.
Causes of Death in New York.

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May 2007 | Wet & Dry Nov 1, 2009 | Chris Eve 2009 [Detail] Blemishes | March 1, 2010 | April 13, 2010 | May 14, 2010 | August 4, 2010 | Sept 3, 2010
Nov 29, 2010 | Jan 17, 2011 | Feb 28, 2011 | May Day, 2011 | July 5 2011 | Sept 11, 2011 | January 10-22, 2012 | July 17, 2012 | Oct 28, 2012 | Dec 31, 2012
March 5, 2013 | March 31, 2013 | May 1, 2013 | June 25, 2013 | July 31, 2013 | August 31, 2013 | Sept 30, 2013 | Oct 27, 2013 | Dec 2, 2013
Dec 31, 2013 | Jan 28, 2014 | Feb 28, 2014 | Mar 30, 2014 | May 8, 2014 | May 30, 2014 | July 31, 2014 | Aug 31, 2014 | Nov 25, 2014
Jan 2, 2015 | Feb 2, 2015 | Mar 7, 2015

pics2012July.html Backup: http://greenray4ever.com/pics2012July.html.

Music[2] || Email[2]: JimGreenHimself@gmail.com. Thanks for sending your pointers, insights, and remarks.