2013 Life Extension Program
on my scalp again, but added
, which promotes the expression of
which elevates endogenous antioxidants
(In July 2012 I substituted bacopa
for ashwagandha, which also
boosts the endogenous antioxidants. However, bacopa elevates thyroid hormone T4, and I took it
1-2 grams with meals for a while to improve my leanness. Furthermore, some vendors now claim
that bacopa is a telomerase activator
although this is not now well documented in
publicly available scientific studies.)
is believed to inhibit the bleaching of hair from the inside out
with endogenous hydrogen peroxide.
is believed to
Instead of applying
Rejuvenating Colostrum Skin Cream
, I mixed up a slurry of bovine
in water and
rubbed it in like a skin cream.
that reconstructs the
including both collagen
It also contains many other telomerase-activating
growth factor skin creams
In addition to mixing
with water to apply it as a skin cream, I have also tried mixing it in olive oil, in
which colostrum is not soluble, however.
Both formulae may be useful, but the solubility of
colostrum in water makes the aqueous formulation most attractive. Perhaps a paste
of powdered colostrum and water would be effective applied as a mask. Colostrum water
may be helpful applied to the scalp.
2013 Recommended Life Extension Program
I was formerly sometimes using
, before reading that some vendors
claim bacopa as a telomerase activator
In June 2011 I used ashwagandha
to upregulate SOD
, relying on
upregulate glutathione peroxidase
during the last half of the month.
should be useful to oppose hair greying
For telomerase upregulation I took 33 g of
/day in March 2013 with
10 mg of astragalosides
I upregulated nerve growth factor
with acetyl L-carnitine
(4 x 400 mg)
and alpha lipoic acid
(4 x 200 mg), which promotes
Id-1 helix-loop-helix transcription factor
which upregulates the production of
In addition, I took rosemary
tea, which also
upregulates nerve growth factor
To activate telomerase in endothelial progenitor cells
I took Ginkgo Biloba
(1.5 grams/dose x 4 doses), which upregulates
HIF-1 transcription factor
(10 grams), which upregulates
was upregulated with whey protein and
1.5 grams of arginine
plus 1.5 grams of
In July 2012 I used alpha-GPC
boosting hTERT mRNA levels with HGH
After evening exercise
, I took 620 mg x 5 = 3.25 grams of
extract to upregulate
to remove the
loop closure protein to open
telomere t-loops for access by the telomerase holoenzyme.
a telomerase activator
cardiac cells, muscles and melanocytes, and provides
another HIF-1 transcription factor
At this low dose, no undesired transformations
are expected from Fenugreek
phytoestrogens when the application period is just two weeks.
Upgrades for 2013
Cycloastragenol and Astragalus Extract for Primary Telomerase Activation
In April 2011 I used experimenter's cycloastragenol
(10 mg/day) from a chemical supply company for the rejuvenation application for
the first 15 days of the month, plus a couple of bottles of
astragalus root extract
1 mg astragalosides
per 30 drops),
which I applied to my scalp.
I tried in 2011 to put the cycloastragenol in via a transdermal route of application scheme.
By July 2012 I concluded from studies done by the
Calvin B. Harley
that astragalus root
at 25-33 grams/day would be more effective than cycloastragenol (25 mg/day), TA-65 (25 mg/day), or
astragaloside IV (100 mg/day)
for lengthening telomeres to obtain rejuvenation effects.
I tried shelling astragalus root powder out of gelatin capsules, mixing it as a suspension in water,
and heating it up to be served as a tea with sweetener.
Although you have to stir the mixture with a spoon because it somewhat settles out of solution,
this may be easier than swallowing 66 x 500 mg capsules throughout the day.
I finally settled in March 2013
for 4 doses of astragalus root pills during the day, 9 grams + 8 grams + 8 grams + 8 grams = 33 grams
= 18 caps + 16 caps + 16 caps + 16 caps.
Forskolin & Tribulus for Hair Darkening Improvements
I started taking Forskolin
to darken my hair toward the end of the month in 2011,
after I read that Forskolin
darkens hair, and upgraded my
index entry on the topic.
also elevates the expression of testosterone
which promotes reverse cholesterol transport and
activates telomerase in muscle tissues and hair follicles via the androgen receptor.
also darkens hair by increasing the expression of
Thymic Restoration with Telomerase Activation from Nitric Oxide
In April 2011 and July 2012 I used 10 grams of
per day during the
first 15 days of the month in order to stimulate the
restore youthful levels of
endothelial progenitor cells
Confining High Vitamin D to Telomerase Inhibition Periods
Otherwise, I followed the routine from the prior month,
except that I used high vitamin D
levels only during the final
15-day telomerase inhibition periods
as I confirmed in February that Vitamin D3
Nicotinamide to Improve the Hayflick Limit
I tried again to follow Kang's advice on nicotinamide
which has extended life spans
of cells in the lab by a factor of 1.6. (See Kang HT, Lee HI, Hwang ES (2006),
replicative lifespan of Human Cells
, 5(5): 423-36.)
This is due to fewer
telomeric repeats lost per cell division
so that cells can divide more.
In April 2011 I could obtain 500 mg capsules of
a form of niacin
, also a form of
which I added to my usual 4 daily
Super B-Complex pills
including 100 mg of niacinamide
, also called
], in addition to
and material functioning like a
I took the nicotinamide
recommended by Kang, 500 mg in the morning and 500 mg before bedtime.
Nicotinamide to Increase Tankyrase Expression and NAD+ levels for opening T-Loops
I note that my recent research shows that niacinamide
can be taken < 3 grams/day (while taking
a telomerase activator
to provide the NAD+ substrate
required by tankyrase 1
to strip TRF1 telomere binding protein
opening telomere loops
for telomerase access and subsequent extension of the telomere.
] can be
taken directly as a supplement to enhance
t-loop closure protein stripping.
Furthermore, insulin boosters
can be used at the end of a workout to
phosphorylate tankyrase 1
making it active for this reaction.
tankyrase 1 expression
is known to be enhanced by niacinamide
so that in May for the first time I will be consciously opening telomere loops with
acting on them with telomerase expressed via the upregulation of hTERT mRNA levels using small
molecule telomerase activators
Boosting HGH levels for growth hormone telomerase activation
I also used whey protein
up as high as possible
to get higher hTERT
mRNA levels to
support telomerase activity (7)
However, unless I get behind heavier iron,
nothing much will happen to my physical size from doing pushups, curls with light dumbells, and
other light exercise, although my HGH
levels are high.
is actually more anabolic
for supporting muscle growth
and avoiding old age sarcopenia.
I had to do 35 pull-ups with 100 lb chained on to get 19 inch arms back when I was
really doing some bodybuilding
could usually get me through sticking points, which is how I pressed 300 lb at 48.
Creatine monohydrate also elevates IGF-1
levels and lead to 10% - 12% longer lifetime in experimental animals.
ought to eventually produce a leaner, more photogenic look.
I don't know why I find
such a devilish challenge.
Telomerase Activation On Period (1st 15 days of the month)
, as an HDAC inhibitor
___to activate hTR
and hTERT transcription from mesenchymal-derived cells.
is required for proper telomerase function, 5 grams/day during activation phase.
___Glutamine may be taken from fish or meat to economize telomere therapy.
NOW astragalus root
mixed with water and served as a tea with sweetener.
____Formerly 10 mg/day cycloastragenol
(10 mg in skin cream at bedtime),
____[but preferably 25 mg of cycloastragenol
4 mg astragalosides
/day to the scalp from
____GAIA Herbs Astragalus
, 30 drops per 1 mg astragalosides
4 x (175 mg/cap) capsules/day of black cohosh
extract taken orally.
3.25 grams/day of Fenugreek
extract (5 x 620 mg taken orally before bedtime)
-mediated transcription of hTERT mRNA.
____Also provides insulin
to phosphorylate tankyrase 1
____with TRF1 protein
-mediated transcription of hTERT mRNA.
taken orally (4 x 500 mg/day) and as a
(6 x 500 mg/day in 1/6 cup water).
____Colostrum transcribes hTERT mRNA
uses the MAPK pathway
____and contains telomerase activators
(4 x 25 mg/day)
for telomerase-activating testosterone
(1-2 grams/day) for supplemental
-mediated transcription of hTERT mRNA.
as an HGH
secretagogue and telomerase activator via
activates transcription of
, including Rosemary tea (extract) and
Essential Oil of Rosemary
____to elevate Nerve Growth Factor
and levels of
ID-1 helix-loop-helix transcription factor
< 3 grams (NOW Foods
), to enable
____and improve the Hayflick cell division limit
(Kang, et al, 2006
(tuna, skim milk, grapefruit, pineapple).
Every Day of the Month
to elevate levels of
____which phosphorylates cytoplasmic hTERT protein
for import into the nucleus.
also activates the
____away from the cellular nucleus,
reducing expression of caveolin-1
leading to senescence.
____Reduced expression of caveolin-1
to recovery from cellar senescence
also provides ATP for synthesis of
____for recovery from senescence
for telomerase activation
heart stem cells, muscle stem cells, and hair folicle melanocytes.
for recovery from senescence
1 or 2 Equate multivitamin pills
3000 mg of vitamin C
500 mg per serving, distributed over the day.
500 mg x 2 of Nicotinamide (Niacinamide)
(NOW Foods niacinamide
4 x 100 mg Qunol
(a Wal-Mart brand claiming x 3 bioavailability
is required to reduce lipofuscin
and improves lab animal lifetimes 20%.
___More CoQ10 would be safer, although it is costly. By 2012 I take 4x what I took in 2011.
is well-tolerated at
doses of up to 2400 mg/day
4 x (200 mg alpha lipoic acid
+ 400 mg
4 x Acetyl L-Carnitine
____4 x (150 mg vitamin C
100 mg vitamin B1
20 mg vitamin B2
25 mg niacinamide
____2 mg vitamin B6
400 mcg Folic Acid
15 mcg vitamin B12
, 3.8 mcg
____5 mg Pantothenic acid
4 x 400 mg Magnesium
, with 15 mg
(15 mcg vitamin B12
, 3.8 mcg
2000 mg/day, is superior to
for synapse rejuvenation.
from supplements, hard cheeses or select vegetables to deflect tissue calcification.
A walnut/day for alpha linolenic acid and linolenic acid,
essential fatty acids
using a split routine
to cover the body in 3 to 4 days.
__Keep sugar low to avoid sugar glycation
leading to arteriosclerosis
__that threatens elderly ice cream eating exercisers with a subclavian anuerysm.
__A lean gymnastic physique is good for longevity and elderly morale, often puts 20 years on.
Brush and floss your teeth frequently, bleach from time to time. See dental.html
Do under-the-chin platysma muscle exercises for
Use Compound W Freeze-Off
to remove skin
and touch up your skin.
Use mild heat stress (sauna, sweat suits) periodically (1 hr 2 x per week) for
Telomerase Inhibition Period (Last 15 days of the month)
4 x 2000 IU, vitamin D3, Super Strength, Spring Valley.
Green Tea every day to the scalp as a
dihydrotestosterone inhibitor, foils hair loss.
Milk Thistle, 4 capsules/day, for silymarin. (by July 2012.)
3 x 2 tablespoons Coca powder in ice water, taken like tea.
4 x Green Tea Tablets
(EGCG 60 mg,
chromium 100 mcg,
apple cider vinegar 500 mg,
____Citrus Aurantium 300 mg).
8 x 200 mg Red Wine Complex
(contains Resveratrol), Spring Valley.
4 x 1000 mg Omega-3
Fish Oil, Spring Valley.
1 x 3 mg Melatonin (Spring Valley Tablet) at bedtime.
Turmeric, taken in water with black pepper to improve
High-Polyphenol diet (tends to generate anticancer
Carrots may taken daily to improve P16INK4A inhibition from retinol
conversion to retinoic acid and to provide more retinoic acid obtained from beta carotene.
Substantial daily bodybuilding
exercise will further inhibit P16INK4A,
promote exercise-induced telomerase activators for telomere maintenance,
lower the LDL/HDL cholesterol ratio, improve lipid profiles, and elevate
reverse cholesterol transport to oppose the development of atherosclerotic plaque.
Costs seem to range between $110 to $200 dollars per month from discount drug stores and health food stores
when astragalus root powder is the mainstay of the program. Ideally, a more expensive program reduces
the amount of
swallowing to be endured. Product B seems to cut the number of pills to
for a 5 < |B| < 8 years/year rejuvenation program to
6 caps per day from 66 caps x 500 mg = 33 gr per day if NOW astragalus root is used. Using the
readily available NOW astragalus root,
a tolerable program uses 4 doses per day of 18 + 16 + 16 + 16 = 66 pills.
However, things go better if
GAIA astragalus root extract
is also rubbed into the skin and scalp from
GAIA Herbs astragalus root extract.
Also, if you are free of atherosclerotic plaque
with normal blood pressure and heartbeat and can
work out with weights, things are
more likely to work out, based on 14 telomerase activators from